How to let rats run perfectly
In a recent blog post, we talked about letting animals walk freely in gait research.
At Noldus, we strongly believe that this is the way to go in gait research, so our CatWalk XT system makes use of free gait. This is consistent with the constant feedback from, and collaborations with, scientists who actually perform gait, locomotor, or pain research.
Stress-less
Working with a closed-off, dark corridor like the CatWalk XT walkway has several advantages. It limits the amount of stress placed on the animal. Besides the obvious effect on the wellbeing of an animal, stress can also cause gait artifacts. The animal may freeze up or lose the desire to move at all. The straight corridor also guides the animal to walk in a straight line, which is beneficial for the footprint measurements.
Lights off please
The dark environment inside the corridor provides the rats with a safe environment, mimicking the natural underground habitat of wild rats. They cannot see the red light in the ceiling that provides the background lighting that is used by the CatWalk XT software. (The CatWalk XT system uses the red ceiling light for body contour lighting, visible in the software and used to automatically classify footprints.)
Mates or food?
Generally, animals quickly learn to cross the corridor. Rats are especially good at this, says Kristina Ängeby Möller, researcher at Karolinska Institute. Although the rats do well crossing the corridor, a little motivation never hurts to get them to cross consistently. She gives some tips on how to positively motivate rats. Does food serve as a good motivator or do friends? You know rats are picky eaters…
Read more in this free white paper, courtesy of Kristina Ängeby Möller.
Get the latest blog posts delivered to your inbox - every 15th of the month
more
Testing motor coordination in a mouse model with muscular dystrophy
Muscular Dystrophy is a broad group of diseases recognized by the loss of muscle mass and strenght. Researchers tried to discover if gene therapy strategies can help with reducing symptoms.
A new sensory and motor scale for the CIA arthritis mouse model
Dr. Bonnefont and her colleagues at IRMB in France just recently proposed a new ArthriSM scale to predict motor and sensory functional deficits in arthritis mouse model. Read more about it in her blog post!