Behavioral Research Blog

Unraveling the chemistry of mood disorders

Posted by Olga Krips on Oct 4, 2013

Long-term behavioral observations with PhenoTyper 

Standard behavioral tests for psychiatric mood disorders
The most common psychiatric disorders are mood and anxiety related. However, the underlying mechanisms of these diseases are still largely unknown. This complicates the development of effective treatment and drugs. There are a large number of standard behavioral tests for mouse or rat models of psychiatric disorders. Many of these tests have a very short duration, between 5 and 60 minutes. Handling the animals prior to the test and their response to the new environment can influence the test results.


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Topics: EthoVision XT, mice, Video tracking, psychiatric disorders, rats, home cage, PhenoTyper

Why it is smart to test your animal in its home cage

Posted by Nico Ouwerkerk on Mar 8, 2013

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Topics: mice, animal behavior research, psychiatric disorders, home cage, PhenoTyper

How researchers are learning to use animal models for psychiatric disorders

Posted by G. Smit on Jul 21, 2011

Recently Lucas Noldus was interviewed for a technology feature in Nature; “Inside the minds of mice and men” by Monya Baker. Nature, 475, 123 - 128.

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Topics: EthoVision XT, Video tracking, animal behavior research, psychiatric disorders, home cage, PhenoTyper

Zebrafish as lab animal increasingly popular

Posted by G. Smit on Jul 8, 2011

One stripe ahead; zebrafish increasingly popular as lab animal

Zebrafish is the new rat. Or mouse. More and more rodents in the lab are being replaced by these nifty little striped fish. They are easy to maintain, reproduce and develop rapidly, and there is a great similarity between the human and zebrafish genome. And because they are easily genetically manipulated, many human diseases and developmental disorders can be modeled in zebrafish, such as Parkinson’s, Alzheimer’s, and cancer.

Like rodents, zebrafish (Danio rerio) can be used in tests investigating fear, stress, and anxiety, learning and memory, and social behavior. And these behaviors can be manipulated by changing their genetics (testing different strains as models for diseases), providing stressful stimuli (tapping on the tank, visuals of predators, etc.) and adding substances (anxiolytics such as buspirone, chlordiazepoxide, and diazepam; anxiogenics; socially relevant substances as ethanol and nicotin) to the water.

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Topics: EthoVision XT, Video tracking, animal behavior research, zebrafish, Danio rerio, exploratory behavior, psychiatric disorders, learning and memory, open field test, anxiety research

NeuroBasic PharmaPhenomics consortium kicks off

Posted by G. Smit on May 25, 2011

Noldus joins in the development of new drug discovery strategies

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Topics: mice, animal behavior research, psychiatric disorders, home cage, PhenoTyper

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